بررسی تغییرات اسپیرومتری و علایم بالینی ریوی در بیماران اسکلرودرمی تحت درمان با سیکلوفسفامید وریدی

Authors

Abstract:

Background & Aims: Scleroderma is a systemic condition with various manifestations in different organs. Among these organs, the lungs are affected very frequently, and the involvement is progressive and significant. Various medications have been suggested and tested in patients with scleroderma and lung involvement, but their efficacy and safety profile differ and enforce a difficult final decision-making. Since cyclophosphamide is an example of this kind, this study sought to examine the therapeutic effect of this drug in patients with scleroderma and lung disease. Materials & Methods: A total of 20 patients with scleroderma and lung parenchymal disease received intravenous cyclophosphamide (750 mg/m2) along with gradually tapering prednisolone (20-7.5 mg/day) and azathioprine (2mg/kg) after discontinuation of the former for six consecutive months. The Transition Dyspnea Index (TDI), Forced Vital Capacity (FVC), Total Lung Capacity (TLC), 17 revised Rodnan Score were examined three and six months after starting the treatment. Results: Six months after treatment, significant changes in FVC (p = 0.55), TLC (p = 0.39), FEV1 (p=0.27), 17 revised Rodnan Score (p=0.98) was not observed. The TDI also did not show significant changes during the six months of treatment (p = 0.79). Based on the type of antibody was not seen significant difference in the amount of TDI. Conclusion: Administration of intravenous cyclophosphamide in the treatment of scleroderma in patients with pulmonary involvement of our study did not have considerable effects on pulmonary function and clinical manifestations that were similar to other studies in this field. SOURCE: URMIA MED J 2016: 27(6): 475 ISSN: 1027-3727

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

مقایسه تأثیر وضعیت طاق باز و دمر بر وضعیت تنفسی نوزادان نارس مبتلا به سندرم دیسترس تنفسی حاد تحت درمان با پروتکل Insure

کچ ی هد پ ی ش مز ی هن ه و فد : ساسا د مردنس رد نامرد ي سفنت سرتس ي ظنت نادازون داح ي سکا لدابت م ي و نژ د ي سکا ي د هدوب نبرک تسا طسوت هک کبس اـه ي ناـمرد ي فلتخم ي هلمجزا لکتورپ INSURE ماجنا م ي دوش ا اذل . ي هعلاطم ن فدهاب اقم ي هس عضو ي ت اه ي ندب ي عضو رب رمد و زاب قاط ي سفنت ت ي هـب لاتـبم سراـن نادازون ردنس د م ي سفنت سرتس ي لکتورپ اب نامرد تحت داح INSURE ماجنا درگ ...

full text

بررسی علایم بالینی بیماران مبتلا به اسکلرودرمی نوع محدود و منتشر پوستی در سه سال اولیه شروع بیماری و مقایسه آن با شش سال پس از شروع اسکلرودرمی

Systemic sclerosis is a generalized disorder of connective tissue, in which the pattern of disease extent, progression and outcome is heterogenous. To determine clinical features, disease extent and progression, we studied our patients in two phases of disease early (the first 3 years) and late phases (after 6 years of disease). 19 patients had diffuse cutaneous and 34 patients had limited cuta...

full text

علایم و نشانه‌های بالینی و پیامد درمان در کیست هیداتید ریوی عارضه دار

چکیده مقدمه: کیست هیداتید بیماری انگلی است که توسط اکی‌نوکوکوس گرانولوزیس و ندرتاً اکی نوکوکوس مولتی لکولاریس ایجاد می شود. کبد و پس از آن ریه شایع‌ترین محل ابتلا می‌باشند. چون علایم بالینی وتشخیص و پیامد درمان در بیماران مبتلا به کیست هیداتید ریوی عارضه دار به خوبی بیان نشده است لذا بر آن شدیم که مسایل فوق را بررسی نمایم. هدف: بررسی، علایم، نشانه‌های بالینی، تشخیص و پیامد درمان در بیماران ...

full text

اثر بربرین در تنظیم آستروسیتهای Gfap+ ناحیه هیپوکمپ موشهای صحرایی دیابتی شده با استرپتوزوتوسین

Background: Diabetes mellitus increases the risk of central nervous system (CNS) disorders such as stroke, seizures, dementia, and cognitive impairment. Berberine, a natural isoquinolne alkaloid, is reported to exhibit beneficial effect in various neurodegenerative and neuropsychiatric disorders. Moreover astrocytes are proving critical for normal CNS function, and alterations in their activity...

full text

اثر بربرین در تنظیم آستروسیتهای Gfap+ ناحیه هیپوکمپ موشهای صحرایی دیابتی شده با استرپتوزوتوسین

Background: Diabetes mellitus increases the risk of central nervous system (CNS) disorders such as stroke, seizures, dementia, and cognitive impairment. Berberine, a natural isoquinolne alkaloid, is reported to exhibit beneficial effect in various neurodegenerative and neuropsychiatric disorders. Moreover astrocytes are proving critical for normal CNS function, and alterations in their activity...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 27  issue 6

pages  466- 475

publication date 2016-09

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023